Having scanned through some discussions by TOK teachers throughout the world (they have a discussion forum too!), here are some more thoughts about knowledge issues and what they are:
1. A KI attempts to establish the status of knowledge claims. In other words, it distinguishes between real knowledge, so to speak, and pseudo-knowledge: claims that pretend to be knowledge. For example, consider the claim 'I know that souls exist after they die'. What helps us to establish this as true knowledge? What hinders us? Is this knowledge a powerful tool for the advancement of humanity? Or is it simply a bogus claim to exploit people into joining a religious cult? How do we know the difference? Answer: identify the KIs implicit in the claim...
2. A KI is something that identifies not only the 'weaknesses' of knowledge, but also its 'strengths'. After all, knowledge can be a powerful tool in life and wielded for good or evil.
3. The phrasing of a KI (usually in the form of a question) should allow you to explore differing views on the answer. Your essay or presentation should actively engage with these differing views (the arguments and counter-arguments).